Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin.
نویسندگان
چکیده
Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses.
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ورودعنوان ژورنال:
- Bioconjugate chemistry
دوره 18 6 شماره
صفحات -
تاریخ انتشار 2007